United boast an imperious record over their visitors, having won 17 and lost none of their last 22 Premier League games against the North Londoners.
Spurs will be desperate to address that hoodoo when they make the trip north this weekend, but could face a tough task against a Red Devils side who are currently second in the fledgling table.
Sir Alex Ferguson's men are yet to set the league alight with their form this season but 12 points from their opening five league games have left them in a solid position, just a point adrift of early leaders Chelsea.
Tottenham, meanwhile, have made up for a lacklustre start with back-to-back wins against Reading and QPR to sit eighth in the table with eight points.
The jury still appears to be out on new Spurs boss Andre Villas-Boas, who replaced Harry Redknapp in the summer, but victory over United would no doubt see the Portuguese's stock rise.
However, with United having won their last six consecutive games in all competitions without ever really hitting top gear, Spurs could have their work cut out on Saturday.
Villas-Boas will be boosted by the form of Jermain Defoe, who has scored four goals for Tottenham and two for England so far this season and will be on the hunt for his 200th career goal at Old Trafford.
